Contribution to the Development of Polymer-based Pharmaceutical Dosage Forms

Throughout the years, the main focus of the research activity was the applicability of different types of carboxyvinyl polymer, commercially available as Carbopols. Given the fact that the PhD thesis focused mostly on development of cutanous gel formulations, based on two traditional (Carbopol 940 and Carbopol 980) and one newly developed carboxyvinyl-type polymer (Ultrez 10), further research was conducted to enlarge to applicable polymers (for ex. by using Ultrez 21) for hydrogel formation, but also to incorporate different pharmaceutical active ingredients. Comparative in vitro dissolution test were performed in order to quantify the released active ingredient from the hydrogels. Numerous active pharmaceutical ingredients were incorporated in different gel bases, formulated with carboxyvinyl-type polimers, but also, by employing other polymers, such as methylcellulose or carboxymethylcellulose.